Synapticure launches a study for presymptomatic ALS patients

This study will assess the tolerability and efficacy of Riluzole in presymptomatic individuals who carry a pathogenic or likely-pathogenic gene variant.

Parkinson's Disease

Amyotrophic Lateral Sclerosis

Primary Lateral Sclerosis

18 years and older

Anyone 18 years old and older who is a carrier of a pathogenic or likely-pathogenic ALS-associated gene variant and is presymptomatic or asymptomatic.

Carry a genetic variant

You are likely eligible to enroll if you carry a variant in ANXA11, C9orf72, CHMP2B, FUS, SOD1, KIF5A, NEK1, OPTN, PFN1,TARDBP, TBK1, VAPB, VCP, or UBQLN2, or other ALS-associated genes that have been categorized as likely-pathogenic.

Virtual Access

You must be able to meet virtually via a telemedicine platform on a monthly basis with their Synapticure care coordinator, every three months with their Synapticure neurologist and twice yearly with an independent neurologist for a face-to-face visit.


Visits may be covered by insurance, may require a co-pay, or may be an out-of-pocket expense. The co-pay for most Synapticure patients falls between $0-40 per visit, and we estimate medication will cost less than $20 per month.

Keep in Touch

Not ready to book? Sign up!

Stay tuned on updates from team Synapticure on the latest research, insights and innovations in ALS Disease

Physician Spotlight

Dr. Jaime Hatcher-Martin, one of Synapticure's Neurologists with whom you can book a virtual appointment

Jaime Hatcher-Martin, MD

Synapticure’s Movement Disorder team is led by Dr. Jaime Hatcher-Martin, a long-standing advocate for the use of telemedicine to democratize expert neurological care and reduce patient burdens. Prior to joining Synapticure, Dr. Martin practiced at Emory University where she started her own telemedicine clinic for patients with movement disorders in Georgia in 2016, and SOC Telemed (now Access Telecare).

She is a Fellow of the American Academy of Neurology, served as co-Chair for their Telemedicine Workgroup as well as many other telehealth subcommittees, and is on the Telemedicine Study Group for the International Parkinson and Movement Disorder Society.

ALS Neurologist, Dr. Danielle Geraldi-Samara

Physician Spotlight

Danielle Geraldi-Samara, MD

Synapticure’s Neuromuscular Service Line is led by Dr. Danielle Geraldi-Samara, a fellowship trained neuromuscular specialist with a career-long focus on ALS and other motor neuron diseases.  Dr. Geraldi-Samara launched and supervised two community based ALS clinics prior to joining Synapticure

After graduating from the State University of New York at Syracuse with her MD, she completed both her neurology residency and clinical neurophysiology/neuromuscular fellowship training at the Mount Sinai School of Medicine in NY, NY, where she was also selected to serve as Chief Resident during her final year of training.

Make an appointment

Register here for Synapticure and schedule an intake call. No worries — the intake is 100% free and allows us to talk about your diagnosis and current health-related needs.

Talk to our team

After deciding to continue care with
Synapticure, schedule a followup with one
of our amazing Neurology specialized doctors. We'll talk as long as we need to understand your history—no cutoff times.

We'll do the rest

We'll gather your full medical history and coordinate with your Primary doctor, if you wish to keep us secondary. Prescription refills, and follow-up visits from your phone.

Working with synapticure

Clinic visits from home

Regular visits with your doctor are important in tracking your progression and regulating medications. We make those check-ins as painless as possible, so that you can get back to living.

Working with synapticure

Experts leading the way

Juggling your care is overwhelming. No more scouring the internet to find local resources or new devices; no more researching new clinical trials and off-label therapies on your own. Let someone else do the work for you.

Working with synapticure

Everything in one place

We coordinate genetic testing and counseling in order to place you in the right clinical trials. We navigate insurance for you, to make sure the medication you need is covered. Our list of in-house services is continually growing, with mental health and psychiatry support on the way.

Mindy Uhrlaub

In 2020, my mom died of C9orf72 ALS. For the last three years, I've cried tears of frustration and grief when I've thought about my family's gene mutation. For the first time, I'm crying tears of joy. This observational study for premanifest gene carriers like me is a game-changer. It could potentially buy me time and give my kids hope for a future without ALS.